What Are The Key Principles And Mechanisms Behind Dr. Seyfried'S Press-Pulse Therapy?

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Introduction

Press-Pulse Therapy: A therapeutic strategy for cancer management that combines chronic and intermittent acute stress on tumor cell energy metabolism.
Calorie Restricted Ketogenic Diets (KD-R): Used to create chronic metabolic stress on tumor cells while protecting normal cells.
Glucose and Glutamine Targeting: Tumor cells rely heavily on glucose and glutamine for energy, making them vulnerable to therapies that restrict these fuels.
Ketone Bodies: Elevated ketone bodies protect normal cells from energy stress and enhance stress in tumor cells.
Hyperbaric Oxygen Therapy (HBOT): Used to selectively increase oxidative stress in tumor cells.
Stress Management: Techniques and exercise are incorporated to further stress tumor cell metabolism while improving general health.
Clinical Trials: The strategy can be used as a framework for designing clinical trials for non-toxic cancer management.

Warburg Theory: Cancer cells lose their ability to produce energy using oxygen and rely on fermentation.
Energy Production: Cancer cells depend almost exclusively on glucose for energy.
Dietary Changes: Reducing carbohydrate intake can effectively 'starve' cancer cells.
Mitochondrial Dysfunction: Cancer cells exhibit mitochondrial abnormalities, leading to reliance on fermentation.
Systemic Disease: Cancer is considered a singular systemic disease, not just a collection of individual tumors.

Press Disturbances: Create chronic metabolic stress on tumor cell energy metabolism.
Pulse Disturbances: Produce acute metabolic stress by restricting glucose and glutamine availability.
Oxidative Stress: Pulse therapies stimulate cancer-specific oxidative stress.
Ketone Bodies: Protect normal cells and enhance stress in tumor cells.
Combination Approach: Integrates diet, drugs, and procedures to target tumor metabolism.

Primary Fuels: Tumor cells rely heavily on glucose and glutamine.
Energy Production: Glucose and glutamine drive dysregulated tumor growth.
Therapeutic Targeting: Restricting these fuels makes tumor cells vulnerable.
Metabolic Stress: Targeting glucose and glutamine creates metabolic stress in tumor cells.
Supplementation: Ketone body supplements can further reduce glucose levels.

Oxidative Stress: Increases oxidative stress in tumor cells.
Selective Targeting: Works synergistically with press therapies.
Tumor Vulnerability: Tumor cells are less capable of adapting to oxidative stress.
Normal Cells: Protected from oxidative stress by elevated ketone bodies.
Therapeutic Integration: Combined with diet and other therapies for maximum effect.