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Introduction

  • Press-Pulse Therapy: A therapeutic strategy for cancer management that combines chronic and intermittent acute stress on tumor cell energy metabolism.

  • Calorie Restricted Ketogenic Diets (KD-R): Used to create chronic metabolic stress on tumor cells while protecting normal cells.

  • Glucose and Glutamine Targeting: Tumor cells rely heavily on glucose and glutamine for energy, making them vulnerable to therapies that restrict these fuels.

  • Ketone Bodies: Elevated ketone bodies protect normal cells from energy stress and enhance stress in tumor cells.

  • Hyperbaric Oxygen Therapy (HBOT): Used to selectively increase oxidative stress in tumor cells.

  • Stress Management: Techniques and exercise are incorporated to further stress tumor cell metabolism while improving general health.

  • Clinical Trials: The strategy can be used as a framework for designing clinical trials for non-toxic cancer management.

Metabolic Theory of Cancer [1]

  • Warburg Theory: Cancer cells lose their ability to produce energy using oxygen and rely on fermentation.

  • Energy Production: Cancer cells depend almost exclusively on glucose for energy.

  • Dietary Changes: Reducing carbohydrate intake can effectively 'starve' cancer cells.

  • Mitochondrial Dysfunction: Cancer cells exhibit mitochondrial abnormalities, leading to reliance on fermentation.

  • Systemic Disease: Cancer is considered a singular systemic disease, not just a collection of individual tumors.

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Mechanisms of Press-Pulse Therapy [2]

  • Press Disturbances: Create chronic metabolic stress on tumor cell energy metabolism.

  • Pulse Disturbances: Produce acute metabolic stress by restricting glucose and glutamine availability.

  • Oxidative Stress: Pulse therapies stimulate cancer-specific oxidative stress.

  • Ketone Bodies: Protect normal cells and enhance stress in tumor cells.

  • Combination Approach: Integrates diet, drugs, and procedures to target tumor metabolism.

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Role of Ketogenic Diet [1]

  • Calorie Restriction: Reduces systemic glucose availability.

  • Ketone Bodies: Provide an alternative energy source for normal cells.

  • Therapeutic Ketosis: Aggressively triggered and maintained through diet.

  • Water Fasting: Recommended for three to five days before starting the diet.

  • Diet Composition: Consists mostly of fat (up to 80% of calories) and protein.

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Glucose and Glutamine Targeting [2]

  • Primary Fuels: Tumor cells rely heavily on glucose and glutamine.

  • Energy Production: Glucose and glutamine drive dysregulated tumor growth.

  • Therapeutic Targeting: Restricting these fuels makes tumor cells vulnerable.

  • Metabolic Stress: Targeting glucose and glutamine creates metabolic stress in tumor cells.

  • Supplementation: Ketone body supplements can further reduce glucose levels.

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Hyperbaric Oxygen Therapy [2]

  • Oxidative Stress: Increases oxidative stress in tumor cells.

  • Selective Targeting: Works synergistically with press therapies.

  • Tumor Vulnerability: Tumor cells are less capable of adapting to oxidative stress.

  • Normal Cells: Protected from oxidative stress by elevated ketone bodies.

  • Therapeutic Integration: Combined with diet and other therapies for maximum effect.

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Stress Management Techniques [2]

  • Exercise: Incorporated to further stress tumor cell metabolism.

  • General Health: Improves overall health and well-being.

  • Synergistic Effect: Works with other therapies to enhance effectiveness.

  • Stress Reduction: Techniques to manage and reduce stress levels.

  • Holistic Approach: Combines physical, mental, and emotional health strategies.

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Clinical Applications [2]

  • Non-Toxic Management: Framework for designing clinical trials.

  • Patient Toxicity: Minimizes toxicity while targeting tumor cells.

  • Optimization: Dosing, timing, and scheduling are crucial.

  • Clinical Trials: Used to test the effectiveness of the strategy.

  • Broader Application: Can be applied to most types of cancer.

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Related Videos

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<div class="-md-ext-youtube-widget"> { "title": "Thomas Seyfried, Ph.D.: Press-Pulse - A Novel Strategy for the ...", "link": "https://www.youtube.com/watch?v=9WFxjO3OHy0", "channel": { "name": ""}, "published_date": "Nov 14, 2017", "length": "" }</div>

<div class="-md-ext-youtube-widget"> { "title": "Professor Thomas Seyfried! Metabolic Therapy! Press Pulse!", "link": "https://www.youtube.com/watch?v=0cgrYlOUIoM", "channel": { "name": ""}, "published_date": "1 month ago", "length": "" }</div>

<div class="-md-ext-youtube-widget"> { "title": "Cancer As A Metabolic Disease: Implications For Novel ...", "link": "https://www.youtube.com/watch?v=lOo8NOwwF4g", "channel": { "name": ""}, "published_date": "Oct 16, 2022", "length": "" }</div>