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Introduction

  • FDA Approval: In January 2023, the FDA approved the combination of two targeted drugs, tucatinib (Tukysa) and trastuzumab (Herceptin), for advanced colorectal cancer with excess HER2 protein.

  • Immunotherapy: Recent innovations include immunotherapy, which uses the body's immune system to fight cancer. Notable drugs include dostarlimab, which showed promising results in clinical trials.

  • Minimally Invasive Surgery: Techniques like laparoscopic colon resection and TAMIS (transanal minimally invasive surgery) offer less invasive options with quicker recovery times.

  • Liquid Biopsy: Researchers are exploring liquid biopsies to detect cancer cells or DNA in the blood, potentially guiding treatment and monitoring recurrence.

  • Targeted Therapy: Drugs like bevacizumab (Avastin) and cetuximab (Erbitux) target specific proteins in cancer cells, offering more precise treatment options.

  • Advanced Surgical Techniques: Procedures like cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) are being studied for their effectiveness in treating recurrent colorectal cancer.

FDA Approvals [1]

  • Tucatinib and Trastuzumab: Approved in January 2023 for advanced colorectal cancer with excess HER2 protein.

  • Combination Therapy: These drugs are used together to target specific proteins in cancer cells, improving treatment outcomes.

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Immunotherapy [2]

  • Dostarlimab: An antibody protein that disables the PD-1 and PD-L1 block, allowing the immune system to destroy cancer cells.

  • Clinical Trials: Dostarlimab showed a 100% eradication of tumors in a small study of 89 patients with metastasized colorectal cancer.

  • Future Potential: Opens the door for additional clinical trials and accelerated FDA approval.

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Minimally Invasive Surgery [3]

  • Laparoscopic Surgery: Involves small incisions to remove tumors and affected lymph nodes, leading to quicker recovery times.

  • TAMIS: Transanal minimally invasive surgery for removing small rectal tumors.

  • Robotic Surgery: Uses robotic arms for precision in hard-to-reach areas, reducing recurrence rates.

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Liquid Biopsy [4]

  • Cancer Cells in Blood: Researchers are studying the presence of cancer cells and DNA in the blood of colorectal cancer patients.

  • Guiding Treatment: Liquid biopsies can help guide treatment by identifying specific gene or protein changes.

  • Monitoring Recurrence: Useful for detecting cancer recurrence earlier than imaging tests.

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Targeted Therapy [2]

  • Bevacizumab (Avastin): Prevents tumor from producing VEGF protein needed for new blood vessels.

  • Cetuximab (Erbitux): Inhibits production of EGFR protein, essential for cancer cell growth.

  • Braftovi: Targets cells with BRAF genetic mutation, often combined with EGFR drugs.

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Advanced Surgical Techniques [4]

  • Cytoreductive Surgery (CRS): Removes as much cancer as possible from the abdominal cavity.

  • Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Heated chemotherapy drugs are applied directly to the abdominal cavity during surgery.

  • Hepatic Arterial Infusion Chemotherapy (HAIC): Delivers chemotherapy directly to the liver for cancers that cannot be surgically removed.

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Related Videos

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<div class="-md-ext-youtube-widget"> { "title": "What's new for colorectal cancer treatment?", "link": "https://www.youtube.com/watch?v=z7pkLsLSVDE", "channel": { "name": ""}, "published_date": "Oct 17, 2022", "length": "" }</div>

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